Design and Synthesis of Small and Potent Inhibitors of Urokinase as Antitumor Agents
نویسنده
چکیده
A set of small nonpeptidic diaryl phosphonate inhibitors was prepared. The phosphonate derivatives were synthesized through Birum-Oleksyszyn reaction followed by reduction of the nitro-group which undergo to Boc-protected guanidine derivatives. After removing of Boc-group by TFAA/DCM afford the guanidine phosphonates.
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